Desyrel is the brand name of drug trazodone which is an antidepressant. It is a serotonin antagonist and reuptake inhibitor (SARI). It is used for treating depression. It also has some anti-anxiety and sleep inducing effects. Also, it shows less side-effect than the other drugs.
Mechanism of action
It works by balancing the imbalanced hormones of the brain. Depression happens when the major neurotransmitter serotonin levels are decreased from the brain. Therefore desyrel increases the communication of neurotransmitter so that the balance is maintained. The major neurotransmitters are acetylcholine, nor epinephrine, serotonin and dopamine. If the levels of any of these decreases the mood shift also known as depression by inhibiting the reuptake of serotonin the symptoms of depression are improved.
It is mainly used for anxiety disorder, major depressive disorder, unipolar depression and insomnia. It is not preferred drug for depressions as it causes some side-effects but it can be used as add-on with other drugs. The studies have shown that desyrel is the second choice drug for insomnia.
Dosage and Administration
It comes in tablet form. The usual adult dose of depression is 50mg, 100mg, 150mg, and 300mg. The doses should be monitored and only increased if necessary and with doctor’s consent. Immediate release tablets adult dosage is 150mg orally once a day and increased by 50mg if necessary after 4 days of consuming 150mg, extended release tablets adult dose is 150mg orally once a day and increased by 75mg after 4 days of consuming 150mg. The maximum dose is 400mg.
These are some of the common side-effects:
- light headedness
- unusual tiredness or weakness
- Blurred vision
- muscle or bone pain
- trouble sleeping
- trouble with remembering
- unpleasant taste
Some of the less common or rare side-effects:
- continuing ringing or other unexplained noise in the ears
- hearing loss
- muscle aches or pains
- weight loss
- lack of coordination
- shortness of breath
- pounding in the ears
- muscle tremors
- fast heartbeat
- confusion about identity, tongue, place, and time
- decreased concentration
- general feeling of discomfort
Precaution and warning
If you are allergic then please mention this to your doctor before taking this medicine because it contains some inactive ingredient that may be harmful. Also give your personal and family history to the doctor before taking this medication. Do not consume alcohol as this medicine makes you drowsy while on it. Don’t drive after taking the drug as it makes you dizzy.
Pregnancy and breastfeeding
The studies have not concluded its safety therefore do not use it in first trimester. Same goes for breastfeeding either you discontinue the medicine or discontinue the drug.
The drug that may interact with this medication is digoxin. Also avoid taking the MAO inhibitors with drug as it causes side-effects.