Bupropion is the medication mainly for the treatment of depression and for smoking addiction cessation. It is distributed in the market by the name of Wellbutrin and Zyban group. It is quite popular among the Americans and Canadians as the choice of antidepressant. Bupropion is an effective medication on its own but it is also used as add-on medication for cases of incomplete SSRI antidepressant.
Mechanism of action
Bupron SR works in the brain by increasing the levels of a chemical that helps in communicating in the brain in return it helps by regulating mood. It works same as SSRI by blocking the uptake of nerve cells of serotonin which is as explained above is a brain chemical that makes way for communicating in the brain. Depression is caused by the imbalance of specific neurotransmitters and bupron tablets helps in regulating the said neurotransmitter and increase nor adrenaline and dopamine levels in the brain. Therefore, it is also considered as anti-addictive properties.
Bupron is precisely used for depression and smoking cessation. As mentioned above it has anti-addictive properties that help in smoking cessation as well as depression.
It has also been beneficial in Attention deficit hyperactivity disorder that is also called ADHD.
It is also used in obesity and sexual dysfunction.
Other uses- bipolar depression, mood stabilizer, inflammatory bowel disease, neuropathic pain and also used in treating methamphetamine dependence.
Dosage and Administration
Bupron comes in tablet form and it is taken with a glass of water. The usual adult dosage of Bupropion hydrochloride is 100mg orally twice a day. You can increase the dose after 3 days to 100mg if necessary.
Sustained release tablets and extended-release tablets (wellbutrin) initial dose 150mg orally once a day in the morning. You can increase the dose after 3 days to 150mg if necessary.
Bupropion hydrobromide, extended release tablets (aplenzin) initial dose is 175mg orally once a day in the morning. You can increase the dose after 4 days to 300mg if necessary.
This are some of the most common side-effects:
- irregular heartbeats
- shortness of breath
- trouble sleeping
- dry mouth
More common side-effects:
- Abdominal pain
- Stomach pain
- Decrease in appetite
- Increased sweating
- Weight loss
Rare or less common side-effects:
- Blurred vision
- Change in sense of taste
- Frequent need to urinate
- Unusual feeling of wellbeing
- sore throat
Precaution and warning
Patient should always give full history to the doctor before taking any medication. Do not take any medication by your own always consult the doctor even if you feel cured. Please avoid this drug if you are suffering from seizure.
Pregnancy and breastfeeding
It is safe during pregnancy and breastfeeding only if the potential benefit outweighs the direct risk to the unborn baby.
Drugs like levodopa, amantadine and monoamine oxidase inhibitor such as the antidepressants phenelzine should never be given with bupron.